The efficacy of baclofen has been investigated in numerous clinical trials, but its safety and efficacy in the majority of patients have not been well studied. The present study aimed to evaluate the effect of baclofen on alcohol withdrawal symptoms in a clinical trial involving participants undergoing intrathecal baclofen treatment. We assessed the efficacy of baclofen on the duration of alcohol withdrawal, frequency of alcohol withdrawal, adverse events and discontinuation due to alcohol withdrawal. Thirty-eight patients with intrathecal baclofen treatment were randomly divided into 4 groups (n = 8) by randomization. Group 1 received placebo. Group 2 received baclofen and group 3 received oral baclofen. Group 4 received oral baclofen (50 mg) and group 5 used a modified Baclofen dose (50 mg) and a placebo.
The study was approved by the Ethics Committee of the National Medical University of Warsaw (Ethics Committee approval number: 2015/0014/0/0). Before starting treatment, all participants signed an informed consent form. Patients with a previous history of intrathecal baclofen treatment or a history of intrathecal baclofen withdrawal (either with or without baclofen therapy) were excluded. Participants were eligible for randomization if they were older than 18 years and had been using intrathecal baclofen therapy for at least one month. Inclusion criteria were the following: (1) patients who received intrathecal baclofen therapy, (2) who received at least one dose of intrathecal baclofen, (3) who were able to be in the study, (4) who had had a previous history of intrathecal baclofen treatment, (5) who had ever received intrathecal baclofen therapy and (6) who were taking at least one other medication that could affect the dose of intrathecal baclofen (medication that could affect the dose of intrathecal baclofen). The study was carried out in accordance with the Declaration of Helsinki and the national guidelines on the safety and efficacy of intrathecal therapy. The protocol was approved by the Ethics Committee of the National Medical University of Warsaw (Ethics Committee approval number: 2015/0014/0/0).
The study was approved by the ethics committee. Participants received intrathecal baclofen treatment for at least one month. Participants were instructed to wait at least 1 hour before and 2 hours after the administration of the drug. Participants were instructed to stop treatment at least 1 hour before and 2 hours after baclofen administration and to refrain from alcohol consumption for the specified period of time.
All analyses were performed using SPSS statistical package (IBM Statistics Package version 18.0; SPSS, Chicago, IL, USA). Continuous variables were summarized as mean (standard deviation) or median (interquartile range). The analysis was conducted using the Student t test or the Mann-Whitney U test for continuous variables and the Chi-square test for categorical variables. The significance of the difference was assumed at p< 0.05. All other statistical analyses were performed using SPSS Statistical software version 18.0. For the purpose of the present study, we only used the data of the study to which no adjustment was made in the statistical analysis.
We enrolled 8 patients with intrathecal baclofen treatment. The average age was 51.5 (23.5-74.9) years and all were female. All patients were treated with intrathecal baclofen at a dose of 50 mg daily. All patients had a history of intrathecal baclofen treatment.
Patients with a previous history of intrathecal baclofen therapy were excluded from the study. We divided the study population in 4 groups (n = 8): group 1, 5 mg of intrathecal baclofen and a modified Baclofen dose (50 mg) and a placebo.
In group 1, we received baclofen and oral baclofen at a dose of 50 mg (n = 8); group 2 received intrathecal baclofen, 50 mg, and a placebo. All patients completed a follow-up period of at least two months and were able to continue the treatment. The frequency of alcohol withdrawal in group 1 (n = 8) and the frequency of baclofen withdrawal (n = 8) in group 2 (n = 8) was comparable between the two groups. The frequency of baclofen withdrawal in group 1 (n = 8) was comparable between the 2 groups.
Baclofen is used to treat muscle spasms caused due to cerebral palsy, multiple sclerosis, stroke or due to any other nerve or spinal cord disorders.
Baclofen: Muscle Relaxants
Baclofen is a muscle relaxant. It acts by increasing the effects of certain chemical messengers (such as GABA) in the spinal cord that induces muscle relaxation. As a result, it prevents muscle twitching, relieves pain caused due to muscle spasms and improves muscle movement.
Consult your doctor:
Baclofen has a range of benefits and has been found to be effective in several neurological conditions, including muscle spasms, seizures, hallucinations, and severe tremors.
The Heinach Research Center is a academic research institute with research grant limitations.
If you have any questions or need advice regarding Therapeutic Options for Baclofen, feel free to consult with your doctor.
HypothesisHow long does it take for Baclofen to work?Take as prescribed by your doctor.
It may take several weeks of taking Baclofen for you to feel better. If you stop taking Baclofen and you experience the same or similar side effects, such as hallucinations, dizziness, blurred vision, an erection lasting more than 4 hours and a rapid heartbeat, tell your doctor.
How long does it take for me to see an erection again?If you stop taking Baclofen and you experience any of the side effects, you can have an erection again for up to 4 hours.
For a full list of Therapeutic Options for Baclofen drugs for sale visit.
Baclofen is a muscle relaxant medication primarily used to treat muscle spasms, tension in the muscles of the body and nervous system. Baclofen works by increasing the amount of muscle fibers and muscle relaxation, leading to better mobility, comfort and comfort in everyday activities.
Baclofen is available in various formulations including tablets, capsules, and oral suspension, among others. The medication is primarily prescribed for individuals with:
Baclofen abuse and dependence is a serious medical condition, and patients may experience severe physical and mental complications when taking this medication. Symptoms can include muscle spasms, anxiety, seizures, tremors and rigidity, confusion, and even severe depression.
Baclofen is not approved for the treatment of muscle spasticity. It should only be used for individuals with severe muscle spasticity, and should not be used in children or adolescents who are currently using drugs that can cause muscle spasticity. In severe cases, the use of Baclofen may lead to a life-threatening condition called delirium tremens (MD).
Although Baclofen can be used in the treatment of muscle spasticity, it should not be used in children or adolescents who are currently using drugs that can cause muscle spasticity. It is important for patients to understand that not all muscle spasticity symptoms can be caused by a medication that is used to treat muscle spasticity.
Baclofen can cause a number of serious side effects. These side effects are common and can include:
If a patient has experienced any of these side effects, they should seek medical attention right away. They should seek medical help if they experience any of the following side effects:
Baclofen can cause other side effects such as:
In rare cases, Baclofen may cause serious side effects.
Medically reviewed by Jessica Swirble, PharmDLast updated on April 18, 2025
Drug Information| | |
Baclofen is a medication used to treat muscle spasms, anxiety, and other muscle-related conditions associated with nervous system disorders. It belongs to a class of drugs called skeletal muscle relaxants and antispastic, respectively.
Baclofen is prescribed to be taken orally with meals or up to 1 hour before anticipated sexual activity. It's crucial to complete the full course of treatment to ensure optimal results. If you experience severe side effects or experience some uncommon symptoms, such as muscle pain, nausea, or kidney or liver pain, please consult a healthcare provider immediately.
Baclofen works by blocking a specific enzyme (caspofaicin) that occurs in the nerves that control muscle pain and discomfort. This helps the nerves communicate with one another in the body, reducing pain and discomfort while triggering an influx of another event (axole tolerance) into the body. Baclofen helps alleviate these symptoms by blocking the activity of these natural inflammatory substances in the body, leading to relaxation of the muscles and drowsiness.
While Baclofen is generally well-tolerated, it may cause some side effects in some patients. These symptoms include dizziness, lightheadedness, or headache. Some individuals may experience drowsiness or weight gain as a side effect. It's crucial to inform your healthcare provider of all medications you're taking before starting treatment.
Signs of side effects include nausea, vomiting, dizziness, or headache. If you notice other effects not listed here, please consult your doctor.
The above is not a complete list of potential side effects. If you have any concerns or questions, please call 911 or go to your nearest emergency department.
Baclofen is an oral antispasmodic medication used to treat muscle spasticity (muscle spasms) in adults and children 2 years of age and older. It's crucial to consult a healthcare provider before starting treatment to ensure it's suitable for your condition.
Dosage and treatment should be given to meet the individual's needs, as directed by their doctor. Oral Baclofen is usually taken orally once a day, with or without food.
Consult your doctor if you have questions or experience side effects that are not addressed in the guide section.
Be sure to talk to your doctor about the risks and benefits of Baclofen and any other medications you are taking.
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I am a 32 year old male who has had a total of four episodes in the past year. I am very happy with the results I have received. I am also very pleased with the results I received. The only side effect that I was experiencing that I had not noticed before was sleepiness. I was prescribed baclofen 20 mg. I have had sleep for almost three months now and it is very important that I get sleepiness. I also started taking a pill to control my anxiety and I have been experiencing some anxiety that I was experiencing. The only reason I stopped taking the medication was because of the panic attacks that I was having. I was taking zolmitriptan 20 mg. I had a headache that lasted for 2 hours and I was very sick with a very low dose of 10 mg. I went to the doctor and I did not get the full benefit of the drug but still I had a headache that lasted for 2 hours and I was very sick with a very low dose of 10 mg. I also started taking zolmitriptan 20 mg. I was having sleepiness for 2 hours and I was very sick with a very low dose of 10 mg.
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